| 1 | |  SC Cambuur | 38 | 29 | 5 | 4 | 109 | 36 | 73 | 92 | G21:00 | 12/05/21 | R 38  SC Cambuur 3 NAC Breda 2 G21:00 | 07/05/21 | R 37 Dordrecht 0 SC Cambuur 1 B21:00 | 30/04/21 | R 36 SC Cambuur 1 De Graafschap 1 G22:00 | 23/04/21 | R 35 Jong AZ Alkmaar 2 SC Cambuur 4 G21:00 | 16/04/21 | R 34 SC Cambuur 4 Helmond Sport 1 G21:00 | 09/04/21 | R 33 Den Bosch 3 SC Cambuur 5 |
| 2 | |  Go Ahead Eagles | 38 | 23 | 8 | 7 | 62 | 25 | 37 | 77 | G21:00 | 12/05/21 | R 38 Excelsior Rotterdam 0 Go Ahead Eagles 1 G21:00 | 07/05/21 | R 37 Go Ahead Eagles 2 NEC Nijmegen 1 G15:30 | 02/05/21 | R 36 Go Ahead Eagles 5 Helmond Sport 1 G22:00 | 23/04/21 | R 35 Jong FC Utrecht 0 Go Ahead Eagles 1 G21:00 | 17/04/21 | R 34 Go Ahead Eagles 3 Almere City FC 0 M13:15 | 11/04/21 | R 33 De Graafschap 1 Go Ahead Eagles 0 |
| 3 | |  De Graafschap | 38 | 23 | 8 | 7 | 67 | 47 | 20 | 77 | B21:00 | 12/05/21 | R 38 De Graafschap 0 Helmond Sport 0 B21:00 | 07/05/21 | R 37 Ajax Amsterdam 1 De Graafschap 1 B21:00 | 30/04/21 | R 36 SC Cambuur 1 De Graafschap 1 B22:00 | 23/04/21 | R 35 De Graafschap 2 Almere City FC 2 G21:00 | 19/04/21 | R 34 Jong PSV Eindhoven 0 De Graafschap 2 G13:15 | 11/04/21 | R 33 De Graafschap 1 Go Ahead Eagles 0 |
| 4 | |  Almere City FC | 38 | 22 | 9 | 7 | 75 | 48 | 27 | 75 | B21:00 | 12/05/21 | R 38 Almere City FC 1 Jong PSV Eindhoven 1 G21:00 | 07/05/21 | R 37 Jong FC Utrecht 1 Almere City FC 3 G21:00 | 30/04/21 | R 36 Almere City FC 1 Ajax Amsterdam 0 B22:00 | 23/04/21 | R 35 De Graafschap 2 Almere City FC 2 M21:00 | 17/04/21 | R 34 Go Ahead Eagles 3 Almere City FC 0 B21:00 | 12/04/21 | R 33 Almere City FC 1 Stormvogels Telstar 1 |
| 5 | |  NAC Breda | 38 | 22 | 7 | 9 | 75 | 41 | 34 | 73 | M21:00 | 12/05/21 | R 38 SC Cambuur 3 NAC Breda 2 G21:00 | 07/05/21 | R 37 NAC Breda 2 Maastricht 0 G21:00 | 03/05/21 | R 36 NEC Nijmegen 0 NAC Breda 2 M19:45 | 23/04/21 | R 35 NAC Breda 1 Excelsior Rotterdam 2 B21:00 | 16/04/21 | R 34 Roda JC Kerkrade 3 NAC Breda 3 G19:00 | 09/04/21 | R 33 NAC Breda 3 Jong FC Utrecht 1 |
| 6 | |  Volendam | 38 | 19 | 9 | 10 | 79 | 52 | 27 | 66 | G21:00 | 12/05/21 | R 38 Volendam 2 Jong AZ Alkmaar 1 G21:00 | 07/05/21 | R 37 Jong PSV Eindhoven 0 Volendam 1 B21:00 | 30/04/21 | R 36 Maastricht 2 Volendam 2 G15:30 | 25/04/21 | R 35 Volendam 2 Stormvogels Telstar 0 G21:00 | 16/04/21 | R 34 Jong FC Utrecht 2 Volendam 3 G21:00 | 09/04/21 | R 33 Volendam 5 Helmond Sport 1 |
| 7 | |  NEC Nijmegen | 38 | 20 | 6 | 12 | 68 | 45 | 23 | 66 | G21:00 | 12/05/21 | R 38 NEC Nijmegen 2 Dordrecht 1 M21:00 | 07/05/21 | R 37 Go Ahead Eagles 2 NEC Nijmegen 1 M21:00 | 03/05/21 | R 36 NEC Nijmegen 0 NAC Breda 2 G22:00 | 23/04/21 | R 35 Ajax Amsterdam 0 NEC Nijmegen 1 G19:00 | 16/04/21 | R 34 NEC Nijmegen 3 Jong AZ Alkmaar 2 M21:00 | 09/04/21 | R 33 Excelsior Rotterdam 2 NEC Nijmegen 1 |
| 8 | |  Roda JC Kerkrade | 38 | 15 | 12 | 11 | 67 | 61 | 6 | 57 | M21:00 | 12/05/21 | R 38 TOP Oss 2 Roda JC Kerkrade 0 G21:00 | 07/05/21 | R 37 Roda JC Kerkrade 2 EVV Eindhoven 1 M21:00 | 30/04/21 | R 36 Roda JC Kerkrade 0 Jong AZ Alkmaar 1 M22:00 | 23/04/21 | R 35 Den Bosch 7 Roda JC Kerkrade 0 B21:00 | 16/04/21 | R 34 Roda JC Kerkrade 3 NAC Breda 3 G21:00 | 12/04/21 | R 33 Maastricht 2 Roda JC Kerkrade 4 |
| 9 | |  Excelsior Rotterdam | 38 | 14 | 6 | 18 | 65 | 66 | -1 | 48 | M21:00 | 12/05/21 | R 38 Excelsior Rotterdam 0 Go Ahead Eagles 1 M21:00 | 07/05/21 | R 37 Jong AZ Alkmaar 2 Excelsior Rotterdam 1 G21:00 | 30/04/21 | R 36 Excelsior Rotterdam 3 Dordrecht 0 G19:45 | 23/04/21 | R 35 NAC Breda 1 Excelsior Rotterdam 2 B21:00 | 16/04/21 | R 34 Stormvogels Telstar 1 Excelsior Rotterdam 1 G21:00 | 09/04/21 | R 33 Excelsior Rotterdam 2 NEC Nijmegen 1 |
| 10 | |  TOP Oss | 38 | 13 | 8 | 17 | 40 | 57 | -17 | 47 | G21:00 | 12/05/21 | R 38 TOP Oss 2 Roda JC Kerkrade 0 B21:00 | 07/05/21 | R 37 Helmond Sport 1 TOP Oss 1 B21:00 | 03/05/21 | R 35 Jong PSV Eindhoven 0 TOP Oss 0 M21:00 | 30/04/21 | R 36 TOP Oss 0 Jong FC Utrecht 4 B21:00 | 16/04/21 | R 34 TOP Oss 2 Maastricht 2 G21:00 | 09/04/21 | R 33 Ajax Amsterdam 0 TOP Oss 1 |
| 11 | |  Maastricht | 38 | 13 | 7 | 18 | 50 | 72 | -22 | 46 | G21:00 | 12/05/21 | R 38 Maastricht 3 Den Bosch 1 M21:00 | 07/05/21 | R 37 NAC Breda 2 Maastricht 0 B21:00 | 30/04/21 | R 36 Maastricht 2 Volendam 2 G22:00 | 23/04/21 | R 35 Dordrecht 0 Maastricht 1 B21:00 | 16/04/21 | R 34 TOP Oss 2 Maastricht 2 M21:00 | 12/04/21 | R 33 Maastricht 2 Roda JC Kerkrade 4 |
| 12 | |  Helmond Sport | 38 | 11 | 12 | 15 | 51 | 68 | -17 | 45 | B21:00 | 12/05/21 | R 38 De Graafschap 0 Helmond Sport 0 B21:00 | 07/05/21 | R 37 Helmond Sport 1 TOP Oss 1 M15:30 | 02/05/21 | R 36 Go Ahead Eagles 5 Helmond Sport 1 G19:45 | 23/04/21 | R 35 Helmond Sport 1 EVV Eindhoven 0 M21:00 | 16/04/21 | R 34 SC Cambuur 4 Helmond Sport 1 M21:00 | 09/04/21 | R 33 Volendam 5 Helmond Sport 1 |
| 13 | |  Stormvogels Telstar | 38 | 10 | 11 | 17 | 57 | 61 | -4 | 41 | M21:00 | 12/05/21 | R 38 Stormvogels Telstar 1 Ajax Amsterdam 2 M21:00 | 07/05/21 | R 37 Den Bosch 4 Stormvogels Telstar 1 B21:00 | 30/04/21 | R 36 Stormvogels Telstar 2 Jong PSV Eindhoven 2 M15:30 | 25/04/21 | R 35 Volendam 2 Stormvogels Telstar 0 B21:00 | 16/04/21 | R 34 Stormvogels Telstar 1 Excelsior Rotterdam 1 B21:00 | 12/04/21 | R 33 Almere City FC 1 Stormvogels Telstar 1 |
| 14 | |  Jong PSV Eindhoven | 38 | 10 | 10 | 18 | 54 | 65 | -11 | 40 | B21:00 | 12/05/21 | R 38 Almere City FC 1 Jong PSV Eindhoven 1 M21:00 | 07/05/21 | R 37 Jong PSV Eindhoven 0 Volendam 1 B21:00 | 03/05/21 | R 35 Jong PSV Eindhoven 0 TOP Oss 0 B21:00 | 30/04/21 | R 36 Stormvogels Telstar 2 Jong PSV Eindhoven 2 M21:00 | 19/04/21 | R 34 Jong PSV Eindhoven 0 De Graafschap 2 G21:00 | 09/04/21 | R 33 EVV Eindhoven 0 Jong PSV Eindhoven 2 |
| 15 | |  EVV Eindhoven | 38 | 10 | 10 | 18 | 50 | 62 | -12 | 40 | B21:00 | 12/05/21 | R 38 EVV Eindhoven 2 Jong FC Utrecht 2 M21:00 | 07/05/21 | R 37 Roda JC Kerkrade 2 EVV Eindhoven 1 G21:00 | 30/04/21 | R 36 EVV Eindhoven 1 Den Bosch 0 M19:45 | 23/04/21 | R 35 Helmond Sport 1 EVV Eindhoven 0 G21:00 | 16/04/21 | R 34 EVV Eindhoven 3 Ajax Amsterdam 0 M21:00 | 09/04/21 | R 33 EVV Eindhoven 0 Jong PSV Eindhoven 2 |
| 16 | |  Ajax Amsterdam | 38 | 10 | 10 | 18 | 55 | 71 | -16 | 40 | G21:00 | 12/05/21 | R 38 Stormvogels Telstar 1 Ajax Amsterdam 2 B21:00 | 07/05/21 | R 37 Ajax Amsterdam 1 De Graafschap 1 M21:00 | 30/04/21 | R 36 Almere City FC 1 Ajax Amsterdam 0 M22:00 | 23/04/21 | R 35 Ajax Amsterdam 0 NEC Nijmegen 1 M21:00 | 16/04/21 | R 34 EVV Eindhoven 3 Ajax Amsterdam 0 M21:00 | 09/04/21 | R 33 Ajax Amsterdam 0 TOP Oss 1 |
| 17 | |  Jong AZ Alkmaar | 38 | 11 | 5 | 22 | 56 | 92 | -36 | 38 | M21:00 | 12/05/21 | R 38 Volendam 2 Jong AZ Alkmaar 1 G21:00 | 07/05/21 | R 37 Jong AZ Alkmaar 2 Excelsior Rotterdam 1 G21:00 | 30/04/21 | R 36 Roda JC Kerkrade 0 Jong AZ Alkmaar 1 M22:00 | 23/04/21 | R 35 Jong AZ Alkmaar 2 SC Cambuur 4 M19:00 | 16/04/21 | R 34 NEC Nijmegen 3 Jong AZ Alkmaar 2 G21:00 | 12/04/21 | R 33 Jong AZ Alkmaar 4 Dordrecht 0 |
| 18 | |  Jong FC Utrecht | 38 | 11 | 2 | 25 | 53 | 77 | -24 | 35 | B21:00 | 12/05/21 | R 38 EVV Eindhoven 2 Jong FC Utrecht 2 M21:00 | 07/05/21 | R 37 Jong FC Utrecht 1 Almere City FC 3 G21:00 | 30/04/21 | R 36 TOP Oss 0 Jong FC Utrecht 4 M22:00 | 23/04/21 | R 35 Jong FC Utrecht 0 Go Ahead Eagles 1 M21:00 | 16/04/21 | R 34 Jong FC Utrecht 2 Volendam 3 M19:00 | 09/04/21 | R 33 NAC Breda 3 Jong FC Utrecht 1 |
| 19 | |  Den Bosch | 38 | 8 | 8 | 22 | 59 | 85 | -26 | 32 | M21:00 | 12/05/21 | R 38 Maastricht 3 Den Bosch 1 G21:00 | 07/05/21 | R 37 Den Bosch 4 Stormvogels Telstar 1 M21:00 | 30/04/21 | R 36 EVV Eindhoven 1 Den Bosch 0 G22:00 | 23/04/21 | R 35 Den Bosch 7 Roda JC Kerkrade 0 G21:00 | 16/04/21 | R 34 Dordrecht 2 Den Bosch 6 M21:00 | 09/04/21 | R 33 Den Bosch 3 SC Cambuur 5 |
| 20 | |  Dordrecht | 38 | 8 | 3 | 27 | 36 | 97 | -61 | 27 | M21:00 | 12/05/21 | R 38 NEC Nijmegen 2 Dordrecht 1 M21:00 | 07/05/21 | R 37 Dordrecht 0 SC Cambuur 1 M21:00 | 30/04/21 | R 36 Excelsior Rotterdam 3 Dordrecht 0 M22:00 | 23/04/21 | R 35 Dordrecht 0 Maastricht 1 M21:00 | 16/04/21 | R 34 Dordrecht 2 Den Bosch 6 M21:00 | 12/04/21 | R 33 Jong AZ Alkmaar 4 Dordrecht 0 |
